nAChR (alpha4beta2)2beta2 Receptor: Regulation of Neuronal Excitability and Neurotransmission

Target Name: Nicotinic (alpha4beta2)2beta2 receptor

NCBI ID: P32845

Nicotinic (alpha4beta2)2beta2 receptor

Other Name(s): nAChR (alpha4beta2)2beta2

nAChR (alpha4beta2)2beta2 Receptor: Regulation of Neuronal Excitability and Neurotransmission

The Nicotinic (alpha4beta2)2beta2 receptor (nAChR (alpha4beta2)2beta2) is a G protein-coupled receptor (GPCR) that plays a crucial role in various physiological processes in the body. It is a member of the nicotinic acetylcholine receptor (nAChR) family , which is a subfamily of GPCRs that are involved in neurotransmitter signaling. nAChR (alpha4beta2)2beta2 is expressed in the central nervous system (CNS) and is involved in the regulation of a wide range of physiological processes, including neuronal excitability, neurotransmitter release, and pain perception.

The nAChR (alpha4beta2)2beta2 receptor is involved in the regulation of neuronal excitability and neurotransmitter release. It is a critical receptor for the neurotransmitter acetylcholine (ACh), which is involved in the regulation of neuronal excitability and neurotransmission. When ACh binds to the nAChR (alpha4beta2)2beta2 receptor, it triggers a signaling cascade that results in changes in neuronal excitability and neurotransmitter release. These changes in turn can have a profound impact on various physiological processes, including muscle contractions, neural communications, and mood regulation.

The nAChR (alpha4beta2)2beta2 receptor is also involved in the regulation of pain perception. Pain perception is a complex physiological process that involves the activation of various neural mechanisms, including the nAChR (alpha4beta2)2beta2 receptor. When damaged tissue is exposed to irritant Substance, such as heat or pressure, the nAChR (alpha4beta2)2beta2 receptor is activated, leading to the release of neurotransmitters such as pain-related corticotomodulins (CPMs) and other pain-related peptides. These neurotransmitters then transmit information about the intensity and location of the pain signal to the brain, leading to the experience of pain.

In addition to its role in pain perception, the nAChR (alpha4beta2)2beta2 receptor is also involved in the regulation of neuronal excitability and neurotransmission in the context of various neurological disorders, including epilepsy and Parkinson's disease. Epilepsy is a neurological disorder that is characterized by the recurrent and sometimes chronic episodes of intense, convulsive episodes. The nAChR (alpha4beta2)2beta2 receptor is involved in the regulation of epileptic seizures, as several studies have shown that blocking or modulating its activity can be an effective treatment for epilepsy.

Parkinson's disease is a neurodegenerative disorder that is characterized by the progressive loss of dopamine-producing neurons in the brain. The nAChR (alpha4beta2)2beta2 receptor is involved in the regulation of dopamine release and uptake, and is therefore a potential target for the treatment of Parkinson's disease. Several studies have shown that blocking or modulating the nAChR (alpha4beta2)2beta2 receptor can be an effective treatment for Parkinson's disease, including using small interfering RNA (siRNA) to knock down the expression of the receptor and improve dopamine levels in the brain.

The nAChR (alpha4beta2)2beta2 receptor is also involved in the regulation of neuronal excitability and neurotransmission in the context of various psychiatric disorders, including depression and anxiety. The nAChR (alpha4beta2)2beta2 receptor is expressed in the postsynaptic terminal of neurons and is involved in the regulation of neurotransmitter release and plasticity. Several studies have shown that changes in the nAChR (alpha4beta2)2beta2 receptor can contribute to the development and progression of depression and anxiety.

In conclusion, the nAChR (alpha4beta2)2beta2 receptor is a GPCR that plays a crucial role in various physiological processes in the body. It is involved in the regulation of

Protein Name: Nicotinic (alpha4beta2)2beta2 Receptor

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